HERe-2 Stay: The Continuing Importance of Translational Research in Breast Cancer
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چکیده
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EDITORIALS HERe-2 Stay: The Continuing Importance of Translational Research in Breast Cancer
This issue of the Journal contains two important articles that discuss human epidermal growth factor receptor 2 (HER2), also known as c-erbB2 or neu, as a therapeutic target in breast cancer (1,2). The first details preclinical studies that examine the combination of trastuzumab with a number of chemotherapeutic agents. The second applies the knowledge learned in the preclinical studies to the ...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولTranslational research in breast cancer.
Translational research (TR) involves both the development of novel diagnostics and novel therapeutics. These two major developmental areas are often associated with each other and these associations often bring new paradigms in the management of cancer patients. For example, the development of trastuzumab-based treatments has been conducted in harmony with the development of new methodologies t...
متن کاملTranslational research in breast cancer.
routine. This also explains the interest of a larger public in these issues; breast cancer activists are willing to take up a role in the creation of biological and clinical databases. Patients are asked to lobby for and help in clinical studies. On the other hand, the access to human tissues is only possible via the patient. The discussion around the Human Tissue Act in Britain may serve as on...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2004
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djh156